The 6 Best Multivitamins with Methylfolate in 2024

A wide range of methylated multivitamins are available on the market now, varying in strength and quality. Here are a few popular options—some of which are ranked as bestsellers—and how they measure up against one another.

This methylated multivitamin includes Quatrefolic, a glucosamine salt form of L-methylfolate. While glucosamine salt forms are not as potent as calcium salt forms, Quatrefolic is a well-known brand of L-methylfolate.

Methyl B Complete also contains TMG Betaine (also known as TMG Trimethylglycine), and Vitamin B12 Methylcobalamin and Adenosylcobalamin, B6, and B2. All Pure Therapro Rx products are made with patented, clinically studied ingredients and free from fillers, excipients and flow agents. Also free from gluten, wheat, soy, corn, yeast, animal products, nuts, artificial preservatives, sweeteners, or colors.

These plant-based formulas contain 23 essential vitamins and minerals to support men’s and women’s health, plus organic fruits and vegetables for whole food nutrition and antioxidants. They contain activated B complex vitamins Methylfolate, B12 as methylcobalamin, and active B6 as P-5-P. The separate formulas target men’s and women’s needs more precisely than a generic multi.

However, the nutrients in the formula are very low-dose: only 400 mcg folate and 2.6 mcg B12. While this meets the RDI (Recommended Dietary Intake), the body only absorbs a small percentage of any nutrient at one time, so the benefits may be minimal.

Awarded the 2018 Chefs Best Excellence Award. Contains Vitamins C and E, B complex vitamins, plus minerals.

Although these are one of Amazon’s best-selling multivitamins, marketed as “an excellent source” of vitamins B12, B6, folic acid, and B5 (pantothenic acid)”, most nutrients are the cheaper forms and in low doses. Vitafusion MultiVites contains folic acid instead of methylfolate and Vitamin B12 as cyanocobalamin which the body does not absorb as well as other forms of B12. Natural berry, peach, and orange flavors, but 3g of sugar per serving. Free from high-fructose corn syrup, artificial sweeteners, gluten, dairy, and synthetic (FD&C) dyes.

This formula contains all-natural sources of vitamins A, Bs, C, D, E, K1, and K2, as well as highly bioavailable minerals. It includes folate (400 mcg as L-5-Methyltetrahydrofolate* fromL-5-Methyltetrahydrofolic Acid, Glucosamine Salt, and 400 mg vitamin B12 (as methylcobalamin).

Designed to provide key nutrients for heart, brain, nerves, immune, bone, and skin health in two capsules a day. Also includes antioxidants, zinc bisglycinate, chromium, and several other well-absorbed, glycinate minerals. NSF Certified for Sport®. Free from all unnecessary additives and preservatives.

Rated #1 multivitamin on consumerLabs.com, this is a science-based multivitamin designed to “meet or exceed” the RDA (Recommended Dietary Allowances) for nearly every ingredient. Made with high-quality raw ingredients. Non-GMO, gluten-free, and manufactured in the USA. A Certificate of Analysis is available for every Life Extension product.

Life Extension Two-Per-Day contains bioactive folate as L-5-methyltetrahydrofolate calcium salt and B12 as methylcobalamin. It also includes zinc citrate, mixed tocopherols as vitamin E, chromium as Crominex®, and a range of patented antioxidants. Gluten free, non-GMO.

Even the most popular multivitamins vary significantly in terms of potency and quality. Reviewing the contents of a particular product is the only way to understand how effective it may be.

Methylfolate, also known as L-methylfolate, is a bioavailable or active form of folate that is essential for many bodily functions, including DNA synthesis and repair, red blood cell formation, and nervous system function. However, some people may have difficulty converting folic acid, the synthetic form of folate found in many supplements and fortified foods, into methylfolate. This is where methylfolate supplements come in.

Methyl-Life® has formulated all its products according to scientific research to ensure optimal benefits. The Chewable Methylated Multivitamin contains only the highest quality ingredients to ensure purity and stability, and it’s a convenient way to support multiple body systems.

For comprehensive MTHFR support, Methyl-Life’s Methylated Multivitamin Bundle is ideal. It includes three MTHFR-targeted supplements: Methylfolate 2.5mg, Hydroxy B12, and the Methylated Multivitamin. This combination provides all of the nutrients required for optimal methylation.

The standout ingredient is Magnafolate® Pro, one of the most stable methylfolates available, along with the equally impressive and rare form, hydroxy B12 as B12 and a range of other highly regarded nutrients. This exclusive formula is so far unmatched in the consumer marketplace.