The 6 Best Multivitamins with Methyl-Folate in 2022

The 6 Best Multivitamins with Methyl-Folate in 2022

Multivitamins are a convenient way to make up for any nutritional gaps in the diet and potentially restore a deficiency. There are hundreds of different brands of multivitamins available these days, and it's important to know that they vary enormously in terms of their formula, ingredients, quality, and potency. 

It’s important to study the label carefully to ensure you choose a multivitamin that provides benefits.

A multivitamin containing methylfolate is a good indication of its quality and efficacy as a whole. Methylfolate is a bioactive form of folate shown to be superior in bioavailability to folic acid, which is a cheaper, synthetic form often used in supplements.

Methylfolate requires no further conversion in the body, so it is immediately available for use in numerous biological processes. For this reason, l-methylfolate is highly recommended for individuals with MTHFR defects who cannot successfully convert folic acid to folate and as a prenatal vitamin for expecting mothers.

Here’s a quick guide on how to choose a quality multivitamin with methylfolate. 

Methyl-Life’s® Chewable Methylated Multivitamin is a highly bioavailable formula with bioactive vitamins, patented minerals, and antioxidants. The methylfolate in this formula is the patented Magnafolate® PRO, clinically tested as one of the market's purest and most stable methylfolates.

This comprehensive multivitamin has been scientifically formulated to assist with proper methylation and overall health. It contains a dose of methylfolate and other nutrients involved in the methylation process, including active B12 as Hydroxocobalamin and active B6 as P-5-P (Pyridoxal-5-Phosphate). It also includes specific coenzymes to optimize the absorption and use of these nutrients in the body, along with key nutrients required for homocysteine metabolism. The chewable tablet ensures easy dosing and maximum absorption via the sublingual route.

The Chewable Methylated Multi also includes Vitamins A, D3, E, bioactive K2, patented minerals, and an ATP energy formula. 

A wide range of methylated multivitamins are available on the market now, with great variations in strength and quality. Here are a few popular options—some of which are ranked as bestsellers—and how they measure up against one another. 

These two plant-based formulas contain 23 essential vitamins and minerals to support men’s and women’s health, plus organic fruits and vegetables for whole food nutrition and antioxidants. They contain activated B complex vitamins Methylfolate, B12 as methylcobalamin, and active B6 as P-5-P. The separate formulas target men’s and women’s needs more precisely than a generic multi.

However, the nutrients in the formula are very low-dose: only 400 mcg folate and 2.6 mcg B12. While this “meets” the RDI(Recommended Dietary Intake), the body only absorbs a small percentage of any nutrient at one time, so the benefits may be minimal.

Vegan, Non-GMO, soy-free, gluten-free.

Awarded the 2018 Chefs Best Excellence Award. Contains Vitamins C and E, B complex vitamins, plus minerals.

Although these are one of Amazon’s best-selling multivitamins, marketed as “an excellent source” of vitamins B12, B6, folic acid, and B5 (pantothenic acid)”, most nutrients are the cheaper forms and in low doses. Vitafusion MultiVites contains folic acid instead of methylfolate and Vitamin B12 as cyanocobalamin which the body does not absorb as well as other kinds of B12. Natural berry, peach, and orange flavors, but 3 g of sugar per serving. Free from high-fructose corn syrup, artificial sweeteners, gluten, dairy, and synthetic (FD&C) dyes. 

This excellent formula contains all-natural sources of vitamins A, Bs, C, D, E, K1, and K2, as well as highly bioavailable minerals. It includes folate (400 mcg as L-5-Methyltetrahydrofolate* fromL-5-Methyltetrahydrofolic Acid, Glucosamine Salt, and 400 mg vitamin B12 (asmethylcobalamin).

Designed to provide key nutrients for heart, brain, nerves, immune, bone, and skin health in two capsules a day. Also includes antioxidants, zinc bisglycinate, chromium, and several other well-absorbed, glycinate minerals. NSF Certified for Sport®. Free from all unnecessary additives and preservatives.

A low-cost multivitamin with most vitamins and minerals in smaller quantities. Contains methylcobalamin as B12 and folate, though the label doesn’t specify the form of folate.

Includes a very small amount of fungal protease, fungal lactase, and lactobacillus acidophilus as probiotics. The low quality and quantity of each item make this a generic supplement rather than therapeutic. Non-GMO, Soy Free, and Gluten-Free.

Rated #1 multivitamin on consumerLabs.com, this is a  science-based multivitamin designed to “meet or exceed” the RDA (Recommended Dietary Allowances) for nearly every ingredient. Made with high-quality raw ingredients. Non-GMO, gluten-free, and manufactured in the USA. A Certificate of Analysis is available for every Life Extension product.

Life Extension Two-Per-Day contains bioactive folate as L-5-methyltetrahydrofolate calcium salt and B12 as methylcobalamin. It also includes zinc citrate, mixed tocopherols as vitamin E, chromium as Crominex®, and a range of patented antioxidants. Gluten free, non-GMO.

Even the most popular multivitamins vary significantly in terms of potency and quality. Reviewing the contents of a particular product is the only way to understand how effective it may be.

Methylfolate, also known as L-methylfolate, is a bioavailable or active form of folate that is essential for many bodily functions, including DNA synthesis and repair, red blood cell formation, and nervous system function. However, some people may have difficulty converting folic acid, the synthetic form of folate found in many supplements and fortified foods, into methylfolate. This is where methylfolate supplements come in.

Methyl-Life® has formulated all its products according to scientific research to ensure optimal benefits. The Chewable Methylated Multivitamin contains only the highest quality ingredients to ensure purity and stability.

The standout ingredient is Magnafolate® Pro, one of the most stable methylfolates available, along with the equally impressive hydroxocobalamin as B12 and a range of other highly regarded nutrients. This exclusive formula is so far unmatched in the consumer marketplace.