MTHFR and Fibromyalgia
Chronic health issues such as fatigue, migraines, depression, cardiovascular disease, and fibromyalgia are now more common than ever. In some cases, these conditions can be related to nutritional status, psychological stress, genetic traits, or a combination of these factors. Most conditions are treated with medication or lifestyle intervention.
In recent decades, connections have been made between the above conditions and specific genetic variants, namely the MTHFR gene.
The methylenetetrahydrofolate reductase gene controls the enzyme that metabolizes folate and its biochemical pathway, methylation.
The methylation process occurs billions of times every second within cells and plays a crucial role in many bodily functions, including detoxification, energy production, and neurotransmitter production. Methylation is also involved in repairing DNA, regulating inflammation, and controlling levels of homocysteine - a harmful amino acid that can damage blood vessels and increase the risk of chronic inflammation.
Various studies indicate that a mutation on the MTHFR gene may play a part in the pathophysiology of fibromyalgia.
This article will explain fibromyalgia and its symptoms as well as its etiology. We will discuss the possible links to MTHFR, particularly regarding research into its impact on glutathione and how those with fibromyalgia may find relief through supplementation with methylated folate.
