Every year, an estimated 7.9 million children1 are born with serious birth defects. More than half of these defects are due to unknown causes, which makes prevention difficult.
Recently, research has drawn possible links between certain health conditions and the MTHFR gene.
MTHFR stands for methylenetetrahydrofolate reductase, an enzyme required for numerous biological processes in the body. This enzyme converts ingested folate into the active form of folate, L-5-Methyltetrahydrofolate (sometimes called 5-MTHF). This is the dominant form used by the body at a cellular level.
A mutation on the MTHFR gene may lead to impaired function of the MTHFR enzyme, which may lead to a deficiency in folate and several other nutrients.
Folate is crucial for the methylation process, which underpins many bodily systems involved with neurological development and function. Methylation is required for switching genes ‘on’ and ‘off,’ as well as building and repairing DNA and converting homocysteine to methionine.
Undermethylation may have serious implications for a child’s development and long-term health. The MTHFR polymorphism has been linked to behavioral disorders (ADHD, autism)2 , food allergies, asthma, mood disorders (depression, anxiety), congenital heart defects, and spinal deformities. It may also influence susceptibility3 to vascular disease, neural tube defects, colon cancer, and acute leukemia.
This article will explain the significance of the MTHFR enzyme regarding children’s health and the most common signs of an MTHFR mutation in children and babies. We will then discuss potential strategies for reducing the risk of MTHFR-related complications through supplementation.
