The 6 Best Multivitamins with Methylfolate in 2025

The 6 Best Multivitamins with Methylfolate in 2025

Katie Stone - Naturopath

Written By:

Katie Stone - Naturopath
Dr. Conor Sheehy - PharmD, BCPS

Medical Reviewer:

Dr. Conor Sheehy - PharmD, BCPS
Kari Asadorian - Bachelor of Science in Nursing

Edited By:

Kari Asadorian - Bachelor of Science in Nursing

Updated On:

March 12, 2025

Table of Contents

    The 6 Best Multivitamins with Methylfolate in 2025

    Multivitamins are a convenient way to fill in any nutritional gaps in the diet and potentially restore a deficiency. There are hundreds of different brands of multivitamins available these days, and it's important to know that they vary enormously in terms of their formula, ingredients, quality, and potency. 

    Study the label carefully to ensure your multivitamin provides what you need.

    Why Choose a Multivitamin with Methylfolate?

    A multivitamin containing methylfolate is a good indication of its quality and efficacy as a whole. Methylfolate is a bioactive form of folate shown to be superior in bioavailability to folic acid, which is a cheaper, synthetic form often used in supplements.

    Methylfolate requires no further conversion in the body, so it is immediately available for use in numerous biological processes. For this reason, L-methylfolate is highly recommended for individuals with MTHFR defects who cannot successfully convert folic acid to folate. It is also safe and recommended for expecting mothers, who have even higher demands for folate.

    Here’s a quick guide on how to choose a quality multivitamin with methylfolate.

    Best Overall: Methyl-Life® Chewable Methylated Multivitamin

    Methyl-Life’s® Chewable Methylated Multivitamin is a comprehensive formula with bioactive vitamins, patented minerals, and antioxidants. The methylfolate in this formula is the patented Magnafolate® PRO, clinically tested as one of the market's purest and most stable methylfolates.

    Methyl-Life® Chewable Methylated Multivitamin has been scientifically formulated to assist with proper methylation and overall wellbeing. It contains a variety of nutrients involved in the methylation process, including active B12 as Hydroxocobalamin and active B6 as P-5-P (Pyridoxal-5-Phosphate). It also contains specific coenzymes to optimize the absorption and use of these nutrients in the body, along with key nutrients required for homocysteine metabolism. Vitamins A, D3, E, bioactive K2, patented minerals, an ATP formula that supports healthy energy levels, immune function, and bone health as well as some special nutrients which support cognition, citicoline and phosphatidylserine.

    The chewable tablet ensures easy dosing and maximum absorption.

    • VitaminB12 Form: Hydroxy B12
    • SupplementType: Chewable tablet
    • Dosage: 1,200 mcg DFE (dietary folate equivalent) methylfolate, 500 mcg B12
    • Count: 120 chewables - 30 servings
    • Certifications and Safety Standards: cGMP registered, NSF certified manufacturer, USP verified

    Other Options for Methylated Multivitamins

    A wide range of methylated multivitamins are available on the market now, varying in strength and quality. Here are a few popular options—some of which are ranked as bestsellers—and how they measure up against one another.

    Pure Therapro Rx Methyl Multi and Methyl B Complete

    This methylated multivitamin includes Quatrefolic, a glucosamine salt form of L-methylfolate. While glucosamine salt forms are not as potent as calcium salt forms, Quatrefolic is a well-known brand of L-methylfolate.
    Methyl B Complete also contains TMG Betaine (also known as TMG Trimethylglycine), and Vitamin B12 Methylcobalamin and Adenosylcobalamin, B6, and B2. All Pure Therapro Rx products are made with patented, clinically studied ingredients and free from fillers, excipients and flow agents. Also free from gluten, wheat, soy, corn, yeast, animal products, nuts, artificial preservatives, sweeteners, or colors.

    • Vegan, Non-GMO, soy-free, gluten-free.
    • VitaminB12 Form: Methylcobalamin
    • SupplementType: Capsule
    • Dosage: 3,400 mcg methylfolate (L-5-Methylfolate), 1000 mcg B12
    • Count: 120
    • Certifications and Safety Standards: NSF/cGMP Certified, FDA-Monitored, 3rd-party tested
    • Contains NAC? No
    • Contains Iron? No
    • Suitable for men and women.
    • Suitable for over 50.

    NATURELO One Daily Multivitamin for Men/Women

    These plant-based formulas contain 23 essential vitamins and minerals to support men’s and women’s health, plus organic fruits and vegetables for whole food nutrition and antioxidants. They contain activated B complex vitamins Methylfolate, B12 as methylcobalamin, and active B6 as P-5-P. The separate formulas target men’s and women’s needs more precisely than a generic multi.

    However, the nutrients in the formula are very low-dose: only 400 mcg folate and 2.6 mcg B12. While this meets the RDI (Recommended Dietary Intake), the body only absorbs a small percentage of any nutrient at one time, so the benefits may be minimal.

    • Vegan, Non-GMO, soy-free, gluten-free.
    • VitaminB12 Form: Methylcobalamin
    • SupplementType: Capsule
    • Dosage: 400 mcg methylfolate (L-5-Methylfolate), 2.4 mcg B12
    • Count: 60
    • Certifications and Safety Standards: cGMP Certified, FDA-Monitored
    • Contains NAC? No
    • Contains Iron? No
    • Suitable for men and women.
    • Suitable for over 50.

    Vitafusion MultiVites Gummy Vitamins

    Awarded the 2018 Chefs Best Excellence Award. Contains Vitamins C and E, B complex vitamins, plus minerals.

    Although these are one of Amazon’s best-selling multivitamins, marketed as “an excellent source” of vitamins B12, B6, folic acid, and B5 (pantothenic acid)”, most nutrients are the cheaper forms and in low doses. Vitafusion MultiVites contains folic acid instead of methylfolate and Vitamin B12 as cyanocobalamin which the body does not absorb as well as other forms of B12. Natural berry, peach, and orange flavors, but 3g of sugar per serving. Free from high-fructose corn syrup, artificial sweeteners, gluten, dairy, and synthetic (FD&C) dyes. 

    • VitaminB12 Form: Cyanocobalamin
    • Supplement Type: Gummy
    • Dosage: 240 mcg folic acid, 4.8 mcg B12
    • Count: 150 gummies
    • Certifications and Safety Standards: GMP-certified, USP verified
    • Contains NAC? No
    • Contains Iron? No
    • Suitable for men and women.
    • Suitable for over 50.

    Thorne Basic Nutrients 2/Day

    This formula contains all-natural sources of vitamins A, Bs, C, D, E, K1, and K2, as well as highly bioavailable minerals. It includes folate (400 mcg as L-5-Methyltetrahydrofolate* fromL-5-Methyltetrahydrofolic Acid, Glucosamine Salt, and 400 mg vitamin B12 (as methylcobalamin).

    Designed to provide key nutrients for heart, brain, nerves, immune, bone, and skin health in two capsules a day. Also includes antioxidants, zinc bisglycinate, chromium, and several other well-absorbed, glycinate minerals. NSF Certified for Sport®. Free from all unnecessary additives and preservatives.

    • VitaminB12 Form: Methylcobalamin
    • SupplementType: Capsules
    • Dosage: 400 mcg folate, 400 mcg B12
    • Count: 60 capsules
    • Certifications and Safety Standards: GMP-certified, NSF-certified, TGA certified
    • Contains NAC? No
    • Contains iron? No
    • Suitable for men and women.
    • Suitable for over 50.

    Double Wood Methylated Multivitamin

    A low-cost multivitamin/B Complex with methylated nutrients. Contains the Methylated / Activated Coenzyme form of Vitamin B2 (R-5-P), Vitamin B6 (P-5P) and Vitamin B12 (Methylcobalamin and Dibencozide), plus trimethylglycine and calcium L-5-methyltetrahydrofolate to assist with homocysteine levels. Can be Combined with a regular multivitamin for those looking to also supplement with other nutrients, such as magnesium and Vitamin D.
    Made in the USA with ‘globally sourced ingredients’. Non-GMO, Gluten Free.

    • Vitamin B12 Form: Methylcobalamin
    • SupplementType: Capsules
    • Dosage: 1666 mg methylfolate, 1000 mcg B12
    • Count: 120 capsules
    • Certifications and Safety Standards: GMP-certified
    • Contains NAC? No
    • Contains Iron? No
    • Suitable for men and women.
    • Suitable for over 50.

    Life Extension Two-Per-Day

    Rated #1 multivitamin on consumerLabs.com, this is a science-based multivitamin designed to “meet or exceed” the RDA (Recommended Dietary Allowances) for nearly every ingredient. Made with high-quality raw ingredients. Non-GMO, gluten-free, and manufactured in the USA. A Certificate of Analysis is available for every Life Extension product.

    Life Extension Two-Per-Day contains bioactive folate as L-5-methyltetrahydrofolate calcium salt and B12 as methylcobalamin. It also includes zinc citrate, mixed tocopherols as vitamin E, chromium as Crominex®, and a range of patented antioxidants. Gluten free, non-GMO.

    • VitaminB12 Form: Methylcobalamin
    • SupplementType: Capsules
    • Dosage: 680 mcg L-5-methyltetrahydrofolate, 300 mcg B12
    • Count: 120 capsules
    • Certifications and Safety Standards: GMP-certified, USP certified
    • Contains NAC? No
    • Contains Iron? No
    • Suitable for men and women.
    • Suitable for over 50.

    Why Choose Methyl-Life®?

    Even the most popular multivitamins vary significantly in terms of potency and quality. Reviewing the contents of a particular product is the only way to understand how effective it may be.

    Methylfolate, also known as L-methylfolate, is a bioavailable or active form of folate that is essential for many bodily functions, including DNA synthesis and repair, red blood cell formation, and nervous system function. However, some people may have difficulty converting folic acid, the synthetic form of folate found in many supplements and fortified foods, into methylfolate. This is where methylfolate supplements come in.

    Methyl-Life® has formulated all its products according to scientific research to ensure optimal benefits. The Chewable Methylated Multivitamin contains only the highest quality ingredients to ensure purity and stability, and it’s a convenient way to support multiple body systems.

    For comprehensive MTHFR support, Methyl-Life’s Methylated Multivitamin Bundle is ideal. It includes three MTHFR-targeted supplements: Methylfolate 2.5mg, Hydroxy B12, and the Methylated Multivitamin. This combination provides all of the nutrients required for optimal methylation. 

    The standout ingredient is Magnafolate® Pro, one of the most stable methylfolates available, along with the equally impressive and rare form, hydroxy B12 as B12 and a range of other highly regarded nutrients. This exclusive formula is so far unmatched in the consumer marketplace.

    Product Recommendations

    Chewable Methylated Multivitamin - L-Methylfolate + Active B12 - MTHFR/Pregnancy/Children - Methyl-Life® Supplements

    Chewable Methylated Multivitamin - L-Methylfolate + Active B12 - MTHFR/Pregnancy/Children
    (28)

    $42.00

    References

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    Katie Stone - Naturopath

    About the Author

    Katie is a qualified Naturopath (BNatMed) and freelance writer from New Zealand. She specializes in all things health and wellness, particularly dietary supplements and nutrition. Katie is also a dedicated runner and has completed more half-marathons than she can count!

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