Are Methylfolate Supplements and Insomnia Linked?
Methylfolate is an essential nutrient required for numerous biochemical processes in the body, namely those related to methylation. The nutrient itself is usually obtained from food or supplements containing folate or folic acid and then converted to methylfolate in the body.
However, an MTHFR polymorphism can prevent the conversion of folic acid, resulting in negative health issues caused by low folate levels. Remedying these levels will usually require supplementation with a bioavailable form of folate called methylfolate. This is the form that can bypass an MTHFR polymorphism and enter the central nervous system.
Although studies evaluating the safe upper limits of folate intake have found methylfolate to be a safe and beneficial nutrient, concerns have been raised regarding excessive intake and a possible link between methylfolate supplements and insomnia.
There is no clinical evidence to support the claim that methylfolate supplements and insomnia are linked. However, some reports show that high doses of methylfolate may increase agitation and potentially lead to mania1
This article will discuss whether methylfolate and insomnia are linked and other possible side effects from taking too large a dose of methylfolate.