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What is Deplin?


What is Deplin?

People all around the world are constantly looking for a way to prevent, manage, and control their depression. It has been reported that over 264 million people suffer from depression across the globe and that number only continues to increase.

Enter Deplin, a prescription product that has been helping patients regain their quality of life by providing your body some of the fundamental nutrition it needs along the methylation pathway. Deplin contains a very powerful form of Vitamin B9 -- L-Methylfolate -- which is essential to mood management, DNA production, and so much more. In fact, it’s the only product to contain 15 mg of Metafolin®, which is one of the patented brand forms of L-Methylfolate.

In recent years, studies have shown that a deficiency in methylfolate is closely linked to depression in patients. SAMe controls our neurotransmitter regulation, including serotonin and those who do not have enough methylfolate can’t promote enough SAMe to keep producing the levels of serotonin needed for optimal mental health. Since our body turns Vitamin B9 into methylfolate, there are several reasons why someone might be deficient. They’ll either struggle to consume enough folate (the active form of Vitamin B9) throughout the day, consume too much folic acid (the synthetic form of Vitamin B9 which actually blocks up the receptors), have a mutation in the process that makes the conversion or be ingesting medication or chemicals that reduce methylfolate amounts in our bodies. 

Deplin is a special product that allows the body to bypass this required folate conversion process in order to directly get the necessary amount of methylfolate into our bodies at the cellular level.

Methylfolate and Depression

One of the many functions of methylfolate in the body is the production of neurotransmitters in the brain. More specifically, methylfolate helps produce serotonin, dopamine, and norepinephrine through SAMe. These neurotransmitters play an important role in mood management and when they aren’t firing on all cylinders, it’ll make us feel depressed or disconnected from our surroundings. 


When people experience depression, they will likely be directed to take an antidepressant. These prescription drugs can help the availability of neurotransmitters in the brain and can help reduce the symptoms in many people. Unfortunately, this won’t work if those people aren’t producing enough neurotransmitters, to begin with. 

This is where Deplin steps in because it’s a product that can be combined with your antidepressant, making it more effective. It’s technically classified as a ‘medical food’ (a fancy way to refer to a vitamin in the prescription world). It’s also considered an ‘adjunct’ prescription (doctors are recommended to prescribe it in conjunction with an antidepressant drug). The idea is that the two will work hand in hand as Deplin produces neurotransmitters and the antidepressant makes them available in the neural pathways.

Is Deplin Right For You?

Since Deplin is a prescription product, you will need authorization from your doctor before adding it to your daily regimen. If you or someone you know has been struggling with depression, L-Methylfolate might be what your body isn’t getting enough of. Your doctor should be able to test the levels in your body and determine if that’s the case. 

Even if you’ve already been instructed to take antidepressants, Deplin can be the missing link your body has been lacking. It’s regarded as generally safe when taken as directed and won’t be packed with many of the side effects that are so common in antidepressants (in fact, many have suggested that it improves their gut health). There have also been 25 clinical trials conducted that support the effects of L-Methylfolate.

If you’re interested in learning more about Deplin, L-Methylfolate, or how you can find alternative ways of managing your depression, contact us at Methyl-Life today. We can help you regain confidence and get back to your better self.


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