Are Stork Bites a Potential Sign of MTHFR?

Written By:

Katie Stone - Naturopath

Medical Reviewer:

Dr. Nare Simonyan - PhD Pharmaceutical Science

Edited By:

Kari Asadorian - Bachelor of Science in Nursing

Updated On:

March 24, 2025

If you’ve had a baby recently, it’s common to find yourself examining your baby and memorizing their precious little faces for as long as the to-do list will allow. In addition to that, you’ll likely be doing a wide variety of research, google searches, article reading, and social media gazing. While you will learn a lot about your baby during this time, you’ll almost always come across something that causes you to worry.

One of the things you might notice on your newborn is a birthmark. These come in various shapes, sizes, and even colors. While most of them will look like a simple discoloration of the skin, some -- like stork bites -- might look a little more harmful than others.

You’ll find yourself running to Google trying to figure out what this big red mark is on your baby. It’ll look like a rash to many, but this very well could just be a birthmark with no intent on harming your baby.

That’s when social media and blogs start to chime in, which is where the worry starts. You begin reading about the MTHFR gene mutation and how it could be linked to your baby’s stork bite. After a few articles and a large amount of information, you start to build this “worst-case scenario” in your head.

If this sounds like you, you’re not alone. Stork bites can be quite the birthmark to find on your child and they will often look worse than they really are. Don’t worry, we’re going to break down everything you need to know about stork bites, the MTHFR gene mutation, and whether you need to be worried at all.

Also Read: Is it possible to take an overdose of vitamin b12 during pregnancy?

What Are Stork Bites?

As we’ve already briefly mentioned, stork bites are a certain type of birthmark found on newborns. They have a rash-like figure to them with their red-pink color and can come in a wide range of sizes. It may surprise most parents, but stork bites are found in nearly 30-50% of all babies.

Stork bites are generally found on the back of the neck, forehead, eyelids, and nose. While they will often occur with little-to-no known cause, we do have a little bit of information on how they form. The red-pink color forms when the blood vessels in that area are stretched or dilated.

In fact, many parents will notice the stork bite becomes more visible when the child is angry, crying, or if they experience a change in temperature. The good news is they are benign, meaning they won’t be harming your baby at all. In a strong majority of cases, the stork bite will fade away as your child gets older -- potentially even completely disappear.

If your child ever wishes to remove the stork bite when they’re older, it is possible through laser treatments. This will also be harmless, but should only be done if the child is bothered by it in their older years.

Also Read: The Link between MTHFR and Depression

What Is MTHFR?

Now that we understand what a stork bite is, let’s go over all this MTHFR gene mutation talk you’ve been seeing all over social media and blogs.

The term MTHFR is short for Methylenetetrahydrofolate reductase. It’s an enzyme responsible for aiding the body’s methylation cycle. The MTHFR enzyme is not to be confused with the MTHFR gene, which supplies the coding for the enzyme.

One of the main functions of MTHFR is converting folate into its active form, methylfolate. You might know Folate (natural form) as Vitamin B9 or folic acid (synthetic form). Without being converted into methylfolate, your body will have no use for Vitamin B9. This will throw off a wide range of body functions.

Scientists, doctors, and researchers have known about the MTHFR gene for quite some time, but it wasn’t until recently that it started to gain widespread attention. This started when scientists found a mutation in the MTHFR gene that disrupted the process of converting folate into the active form.

As a matter of fact, they would end up finding several mutations of the MTHFR gene, though only two of them would raise eyebrows -- C677T and A1298C. Since their discovery, we’ve learned quite a bit about these two mutations.

First off, we know that it’s possible to have zero, one, or two copies of the MTHFR gene mutation. The more you have, the harder it is for your body to convert folate. We also know that the mutations are inherited from your parents since children receive one copy from each parent -- that’s where we get the two copies from.

Having a mutation has been linked to a wide variety of health concerns such as depression, other mental disorders, cardiovascular diseases, and birth defects -- like stork bites.

Also Read: Magnesium: The Solution to More Restorative Sleep?

When can histamine be a problem?

When histamine is present in your bloodstream, it can affect your gut, lungs, skin, brain, and entire cardiovascular system. This results in a variety of unpleasant symptoms. It can also make it difficult to pinpoint histamine as a cause of the symptoms, which complicates the diagnosis.

In most cases, histamine is broken down by enzymes in your body, which prevents it from building up. But if these enzymes aren’t working properly histamine quickly accumulates. This can lead to histamine intolerance.

Because histamine plays so many different parts in how your body functions, symptoms of an intolerance are broad and can easily be confused for other things, such as food allergies.

Is There a Link Between the Two?

We have to be extremely careful when trying to link stork bites to an MTHFR gene mutation. Social media and blogs will try to throw it down your throat that stork bites are a potential sign of MTHFR, but that’s not exactly true.

The truth is scientists haven’t found any link between the two. That doesn’t necessarily mean there isn’t one, but that they haven’t found one yet.

One of the major reasons the two are often linked together is because they’re both highly common in newborn babies. It is estimated that nearly 20-40% of all newborns will suffer from an MTHFR gene mutation, while stork bites are found in nearly 30-40% of newborns. Since it’s more than possible to have both, you can see how they can get mixed together.

There is one instance in particular where a stork bite might be cause for concern and that’s when it is located over the spine. This could be a potential sign of Spina Bifida, a birth defect that disrupts the development of the spine. In this case, Spina Bifida has been linked to MTHFR mutation.

MTHFR has actually been linked to a variety of neural tube birth defects, despite not being directly linked to stork bites.

Also Read: Why Many Lactic Acid-Based Probiotics Don't Work (And How Ours Is Different)

Should You Get Tested Anyway?

Most doctors won’t initiate a test for MTHFR gene mutation, but that doesn’t mean you can’t get one yourself. In fact, a majority of people getting tested for a mutation are doing so out of their own curiosity.

If you’ve noticed a potential birth defect in your child, especially spina bifida, there’s a chance the MTHFR mutation is playing a role. While there will often be several things you need to do to fix the problem, treating the mutation will certainly help.

Keep in mind that children inherit the mutation from their parents. If your child were to have an MTHFR gene mutation, then either you or your husband also have it -- if not both of you. Since a mutation can have negative effects on adults, this is something you’ll want to know. In many cases, you can also find relief even when you didn’t know you needed it.

One of the major concerns with MTHFR gene mutations in adults is high homocysteine levels in the blood. This can lead to pale skin, weakness, fatigue, tingling, dizziness, mouth sores, and mood changes. Those suffering from a mutation can reduce and prevent these concerns in a variety of ways, but most people won’t know they suffer from it.

Finding a Quality Treatment for MTHFR

At Methyl-Life™ we’ve formulated a variety of supplements designed to enhance and optimize the methylation process, especially with those suffering from an MTHFR gene mutation. We understand first-hand how this mutation affects your life and we’ve stayed dedicated to helping others find relief the way we have in our journey.

Whether you just found out you have a mutation or have known for a while, we can help. You can view our full list of supplements on our website, but we’ll highlight some of the most prominent ones you should consider.

First, we have our Methylfolate capsules. These aren’t formulated with anything else but will come in a variety of sizes -- 2.5mg, 5mg, 10mg, and 15mg. Each bottle will come with a three-month supply, keeping you stocked for a while.

If you’re looking for something with a little more zing, we have Methylfolate capsules combined with a multivitamin . You can also find these capsules combined with magnesium and Active Vitamin B12.

For those struggling with what they need, try out one of our bundles. We have one designed for pregnant women, which contains a methylated multivitamin, active Vitamin B12, and Methylfolate 2.5.

Lastly, we have a Beginner’s Bundle. This one comes equipped with Methylfolate 2.5, Active Vitamin B12, a non-methylated multivitamin, and a magnesium supplement.

We understand how complex an issue this can be, especially for someone who was told about their MTHFR mutation out of the blue. The entire concept is still being studied today and researchers are still learning new things about it often.

We do our best to keep our readers informed of what’s new in the MTHFR community and will always be ready to help those that need it. To learn more about our product line, contact us today!

Also Read: Best Vitamins and Minerals to Improve Memory

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References

Erika Krumbeck; "A “Stork Bite” is NOT a sign of MTHFR"; Naturopathic Pediatrics; 2019 Nov

https://naturopathicpediatrics.com/2019/11/22/a-stork-bite-is-not-a-sign-of-mthfr/
Justin Smith; "A Pediatrician Goes In-depth Into MTHFR"; Cook Children's checkupnewsroom.com; 2020 Feb

https://www.checkupnewsroom.com/a-pediatricians-goes-in-depth-into-mthfr/
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About the Author

Katie is a qualified Naturopath (BNatMed) and freelance writer from New Zealand. She specializes in all things health and wellness, particularly dietary supplements and nutrition. Katie is also a dedicated runner and has completed more half-marathons than she can count!

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MTHFR Actives - L-Methylfolate + Hydroxy B12 Sublingual

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